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Antrafenine

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Antrafenine
File:Antrafenine.svg
Systematic (IUPAC) name
2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl 2-{[7-(trifluoromethyl)quinolin-4-yl]amino}benzoate
Clinical data
  • (Prescription only)
Oral
Pharmacokinetic data
Metabolism Hepatic
Excretion Renal
Identifiers
55300-30-6 7pxY
None
PubChem CID 68723
DrugBank DB01419 7pxY
ChemSpider 61973 7pxY
UNII 21FS93Y6OE 7pxY
ChEMBL CHEMBL345524 7pxY
Chemical data
Formula C30H26F6N4O2
588.543 g/mol
 14pxY (what is this?)  (verify)

Antrafenine (Stakane) is a phenylpiperazine derivative drug invented in 1979.[1] It acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen,[2] but is not widely used as it has largely been replaced by newer drugs.

See also

References

  1. ^ Manoury PM, Dumas AP, Najer H, Branceni D, Prouteau M, Lefevre-Borg FM. Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. Journal of Medicinal Chemistry. 1979 May;22(5):554-9.
  2. ^ Leatham PA, Bird HA, Wright V, Seymour D, Gordon A. A double blind study of antrafenine, naproxen and placebo in osteoarthrosis. European Journal of Rheumatology and Inflammation. 1983;6(2):209-11.

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