Central aortic blood pressure (CAP or CASP) is the blood pressure at the root of aorta. Studies have shown the importance of central aortic pressure and its implications in assessing the efficacy of antihypertensive treatment with respect to cardiovascular risk factors. The traditional method of measuring blood pressure in the arms has been shown to underestimate the efficacy of drugs such as amlodipine and overestimate the efficacy of those like atenolol. A clinical trial demonstrated that different medications for lowering blood pressure have different effects on the central aortic pressure and blood flow characteristics, despite producing similar branchial blood pressure readings. The study also indicated that the CAP is a better independent predictor of cardiovascular and renal outcome.
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- Williams B, Lacy PS, Thom SM et al. (March 2006). "Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study". Circulation 113 (9): 1213–25. PMID 16476843. doi:10.1161/CIRCULATIONAHA.105.595496. Lay summary – University of Leicester (2006).
- CAFE - The Conduit Artery Functional Endpoint Study
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- Williams B, Lacy PS, Thom SM et al. (March 2006). "Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study". Circulation 113 (9): 1213–25. PMID 16476843. doi:10.1161/CIRCULATIONAHA.105.595496.
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