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Arbaclofen placarbil
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Systematic (IUPAC) name | |
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(3R)-3-(4-chlorophenyl)-4-[[[(1S)-2-methyl-1-[(2-methylpropanoyl)oxy]propoxy]carbonyl]amino]butanoic acid | |
Clinical data | |
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Identifiers | |
847353-30-4 | |
None | |
PubChem | CID 11281011 |
ChemSpider | 9456008 |
KEGG | D08861 7px |
ChEMBL | CHEMBL2107312 7px |
Chemical data | |
Formula | C19H26ClNO6 |
399.86 g/mol | |
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Arbaclofen placarbil (ar-BAC-loe-fen pla-KAR-bil, also known as XP19986) is a prodrug of R-baclofen. Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen, with less fluctuations in plasma drug levels. It was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis; however, in May 2013 XenoPort announced the termination of development because of unsuccessful results in phase III clinical trials.[1]
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