Open Access Articles- Top Results for Assisted zona hatching

Assisted zona hatching

Assisted zona hatching (AZH) is a procedure of assisted reproductive technology in which a small hole is made in the zona pellucida, using a micromanipulation, thereby facilitating for zona hatching to occur.[1][1] Zona hatching is where the blastocyst gets rid of the surrounding zona pellucida to be able to implant in the uterus.


A systematic review and meta-analysis came to the result that assisted zona hatching is related to increased rates of clinical pregnancy and multiple pregnancy in women with previous repeated failure or frozen-thawed embryos.[2] However, it is unlikely to increase clinical pregnancy rates when performed in fresh embryos transferred to unselected women, to those without poor prognosis or to women of advanced maternal age.[2] Also, overall, there no evidence of a significant difference in live birth rate following assisted hatching compared with no assisted hatching.[3]


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  2. ^ a b Martins, W. P.; Rocha, I. A.; Ferriani, R. A.; Nastri, C. O. (2011). "Assisted hatching of human embryos: A systematic review and meta-analysis of randomized controlled trials". Human Reproduction Update. doi:10.1093/humupd/dmr012.  edit
  3. ^ Farquhar, C.; Rishworth, J. R.; Brown, J.; Nelen, W. L. M.; Marjoribanks, J. (2013). Brown, Julie, ed. "Assisted reproductive technology: an overview of Cochrane Reviews". The Cochrane Library 8: CD010537. PMID 23970457. doi:10.1002/14651858.CD010537.pub2.  edit

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