Open Access Articles- Top Results for Atiprosin


File:Atiprosin structure.png
Systematic (IUPAC) name
Clinical data
  • Uncontrolled
89303-63-9 7pxN
PubChem CID 71770
ChemSpider 64808 7pxY
UNII ALS52889WF 7pxY
ChEMBL CHEMBL2111172 7pxN
Chemical data
Formula C20H29N3
311.46 g/mol
 14pxN (what is this?)  (verify)

Atiprosin (AY-28,228) is an antihypertensive agent which acts as a selective α1-adrenergic receptor antagonist.[1][2][3][4] It also possesses some antihistamine activity, though it is some 15-fold weaker in this regard than as an alpha blocker.[3] It was never marketed.[1]

See also


  1. ^ a b David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. 
  2. ^ Jirkovsky I, Santroch G, Baudy R, Oshiro G (February 1987). "Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents". Journal of Medicinal Chemistry 30 (2): 388–94. PMID 3806618. doi:10.1021/jm00385a022. 
  3. ^ a b Grimes D, Rimele TJ, Henry DE et al. (September 1987). "In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound". Journal of Cardiovascular Pharmacology 10 (3): 249–58. PMID 2444771. doi:10.1097/00005344-198709000-00001. 
  4. ^ Oshiro G, Wojdan A, Klein M, Metcalf G (September 1987). "Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys". Journal of Cardiovascular Pharmacology 10 (3): 341–9. PMID 2444784. doi:10.1097/00005344-198709000-00014.