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Open Access Articles- Top Results for BACH2

BACH2

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Identifiers
SymbolsBACH2 ; BTBD25
External IDsOMIM605394 HomoloGene7240 GeneCards: BACH2 Gene
RNA expression pattern
File:PBB GE BACH2 221234 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez6046812014
EnsemblENSG00000112182ENSMUSG00000040270
UniProtQ9BYV9P97303
RefSeq (mRNA)NM_001170794NM_001109661
RefSeq (protein)NP_001164265NP_001103131
Location (UCSC)Chr 6:
90.64 – 91.01 Mb
Chr 4:
32.24 – 32.59 Mb
PubMed search[1][2]

Transcription regulator protein BACH2 is a protein that in humans is encoded by the BACH2 gene.[1][2][3] It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer [4] and a bZip_Maf domain at the C-terminus.

Model organisms

Model organisms have been used in the study of BACH2 function. A conditional knockout mouse line called Bach2tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[5] Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11] - in-depth bone and cartilage phenotyping[12]





References

  1. ^ Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T et al. (Aug 2000). "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15". Oncogene 19 (33): 3739–49. PMID 10949928. doi:10.1038/sj.onc.1203716. 
  2. ^ Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K et al. (Nov 2003). "B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs". Blood 102 (9): 3317–22. PMID 12829606. doi:10.1182/blood-2002-12-3656. 
  3. ^ "Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2". 
  4. ^ Rosbrook GO, Stead MA, Carr SB, Wright SC (Jan 2012). "The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond". Acta Crystallographica. Section D, Biological Crystallography 68 (Pt 1): 26–34. PMID 22194330. doi:10.1107/S0907444911048335. 
  5. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  6. ^ a b "International Mouse Phenotyping Consortium". 
  7. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337â€"42. PMC 3572410. PMID 21677750. doi:10.1038/nature10163. 
  8. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a. 
  9. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9â€"13. PMID 17218247. doi:10.1016/j.cell.2006.12.018. 
  10. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. PMID 23870131. doi:10.1016/j.cell.2013.06.022. 
  11. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 
  12. ^ a b "OBCD Consortium". 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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