This article is about the human gene. For the German media award, see Bambi award. For other uses, see Bambi (disambiguation).
SymbolsBAMBI ; NMA
External IDsOMIM604444 MGI1915260 HomoloGene8215 GeneCards: BAMBI Gene
RefSeq (mRNA)NM_012342NM_026505
RefSeq (protein)NP_036474NP_080781
Location (UCSC)Chr 10:
28.97 – 28.97 Mb
Chr 18:
3.51 – 3.52 Mb
PubMed search[1][2]

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis), also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.[1][2]


This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.[1]


  1. ^ a b "Entrez Gene: BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)". 
  2. ^ Degen WG, Weterman MA, van Groningen JJ, Cornelissen IM, Lemmers JP, Agterbos MA, Geurts van Kessel A, Swart GW, Bloemers HP (February 1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts". Int. J. Cancer 65 (4): 460–5. PMID 8621228. doi:10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E. 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Lua error in package.lua at line 80: module 'Module:Buffer' not found.