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Open Access Articles- Top Results for BHF-177

BHF-177

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BHF-177
File:BHF-177 structure.png
Systematic (IUPAC) name
N-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-yl]-2-methyl-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinamine
Clinical data
Identifiers
917896-43-6 7pxY
ChemSpider 26286940 7pxY
Chemical data
Formula C19H20F3N3
347.377 g/mol
 14pxY (what is this?)  (verify)

BHF-177 is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.[1] It was shown to reduce self-administration of nicotine in animal studies.[2]

References

  1. Guery, S; Floersheim, P; Kaupmann, K; Froestl, W (2007). "Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABAB receptors". Bioorganic & Medicinal Chemistry Letters 17 (22): 6206–11. PMC 2278029. PMID 17884493. doi:10.1016/j.bmcl.2007.09.023. 
  2. Paterson NE, Vlachou S, Guery S, Kaupmann K, Froestl W, Markou A (2008). "Positive Modulation of GABAB Receptors Decreased Nicotine Self-administration and Counteracted Nicotine-induced Enhancement of Brain Reward Function in Rats". J. Pharmacol. Exp. Ther. 326 (1): 306–14. PMC 2574924. PMID 18445779. doi:10.1124/jpet.108.139204. 



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