Open Access Articles- Top Results for BP-897


File:BP-897 structure.png
Systematic (IUPAC) name
Clinical data
314776-92-6 7pxY
PubChem CID 3038495
ChemSpider 2302059 7pxN
Chemical data
Formula C26H31N3O2
417.542 g/mol
 14pxN (what is this?)  (verify)

BP-897 is a drug used in scientific research which acts as a moderately selective dopamine D3 receptor partial agonist.[1] It has mainly been used in the study of treatments for cocaine addiction.[2][3][4][5][6][7][8]


  1. Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, Schwartz JC, Everitt BJ, Sokoloff P (July 1999). "Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist". Nature 400 (6742): 371–5. PMID 10432116. doi:10.1038/22560. 
  2. Beardsley PM, Sokoloff P, Balster RL, Schwartz JC (February 2001). "The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and D-amphetamine and is not self-administered". Behavioural Pharmacology 12 (1): 1–11. PMID 11270507. doi:10.1097/00008877-200102000-00001. 
  3. Garcia-Ladona FJ, Cox BF (2003). "BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction". CNS Drug Reviews 9 (2): 141–58. PMID 12847556. doi:10.1111/j.1527-3458.2003.tb00246.x. 
  4. Duarte C, Lefebvre C, Chaperon F, Hamon M, Thiébot MH (November 2003). "Effects of a dopamine D3 receptor ligand, BP 897, on acquisition and expression of food-, morphine-, and cocaine-induced conditioned place preference, and food-seeking behavior in rats". Neuropsychopharmacology 28 (11): 1903–15. PMID 12915863. doi:10.1038/sj.npp.1300276. 
  5. Hsu A, Togasaki DM, Bezard E, Sokoloff P, Langston JW, Di Monte DA, Quik M (November 2004). "Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeys". The Journal of Pharmacology and Experimental Therapeutics 311 (2): 770–7. PMID 15226382. doi:10.1124/jpet.104.071142. 
  6. Gilbert JG, Newman AH, Gardner EL, Ashby CR, Heidbreder CA, Pak AC, Peng XQ, Xi ZX (July 2005). "Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors". Synapse (New York, N.Y.) 57 (1): 17–28. PMID 15858839. doi:10.1002/syn.20152. 
  7. Spiller K, Xi ZX, Peng XQ, Newman AH, Ashby CR, Heidbreder C, Gaál J, Gardner EL (March 2008). "The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats". Psychopharmacology 196 (4): 533–42. PMID 17985117. doi:10.1007/s00213-007-0986-6. 
  8. Hocke C, Prante O, Salama I, Hübner H, Löber S, Kuwert T, Gmeiner P (May 2008). "18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor". Chemmedchem 3 (5): 788–93. PMID 18306190. doi:10.1002/cmdc.200700327. 

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