Open Access Articles- Top Results for BRL-44408


File:BRL-44408 structure.png
Systematic (IUPAC) name
Clinical data
118343-19-4 7pxY
PubChem CID 121850
IUPHAR ligand 525
ChemSpider 108707 7pxN
ChEMBL CHEMBL216097 7pxN
Chemical data
Formula C13H17N3
215.293 g/mol
 14pxN (what is this?)  (verify)

BRL-44408 is a drug used in scientific research which acts as a selective antagonist for the α2A adrenoreceptor.[1] It has been suggested as having potential therapeutic application in the treatment of extrapyramidal side effects produced by some antipsychotic medications.[2]


  1. ^ Alberts P (January 1993). "Subtype classification of presynaptic alpha 2-adrenoceptors". General Pharmacology 24 (1): 1–8. PMID 8387042. 
  2. ^ Imaki J, Mae Y, Shimizu S, Ohno Y (April 2009). "Therapeutic potential of alpha2 adrenoceptor antagonism for antipsychotic-induced extrapyramidal motor disorders". Neuroscience Letters 454 (2): 143–7. PMID 19429072. doi:10.1016/j.neulet.2009.03.001. 

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