Open Access Articles- Top Results for Baboon syndrome

Baboon syndrome

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), more popularly known as Baboon syndrome because of its resemblance to the distinctive red buttocks displayed by some male baboon species, is a systemic contact dermatitis characterized by well-demarcated patches of erythema distributed symmetrically on the buttocks.[1] The cause of the syndrome may be drug-related, i.e. induced by systemic administration of hydroxyzine[2] penicillin,[3] iodinated radio contrast media[4] and others.


Baboon syndrome affects both sexes equally, and can occur at any age, but seems to be more common in childhood than in adulthood.[5]

Symptoms and signs

The typical rash commonly appears on buttocks. This then resembles the colour of a baboon’s buttocks. Other areas like upper inner thigh and armpits, may be affected by the rash. The rashes are red and well-defined. The presentation is typically symmetrical and not associated with systemic symptoms.[6]

See also


  1. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  2. Akkari, H.; Belhadjali, H.; Youssef, M.; Mokni, S.; Zili, J. (May 2013). "Baboon syndrome induced by hydroxyzine.". Indian J Dermatol 58 (3): 244. PMID 23723506. doi:10.4103/0019-5154.110871. 
  3. Handisurya, A.; Stingl, G.; Wöhrl, S. (Apr 2009). "SDRIFE (baboon syndrome) induced by penicillin.". Clin Exp Dermatol 34 (3): 355–7. PMID 18699835. doi:10.1111/j.1365-2230.2008.02911.x. 
  4. Arnold, AW.; Hausermann, P.; Bach, S.; Bircher, AJ. (2007). "Recurrent flexural exanthema (SDRIFE or baboon syndrome) after administration of two different iodinated radio contrast media.". Dermatology 214 (1): 89–93. PMID 17191055. doi:10.1159/000096920. 
  5. Moreno-Ramírez, D.; García-Bravo, B.; Pichardo, AR.; Rubio, FP.; Martínez, FC. "Baboon syndrome in childhood: easy to avoid, easy to diagnose, but the problem continues.". Pediatr Dermatol 21 (3): 250–3. PMID 15165206. doi:10.1111/j.0736-8046.2004.21313.x. 
  6. Utaş, S.; Ferahbaş, A. "Baboon syndrome and segmental vitiligo coexistence.". The Turkish Journal of Pediatrics 51 (4): 392–4. PMID 19950853. 

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