Open Access Articles- Top Results for Balsalazide


Systematic (IUPAC) name
(E)-5-([4-(2-carboxyethylcarbamoyl)phenyl]diazenyl)-2-hydroxybenzoic acid
Clinical data
Trade names Colazal, Giazo
AHFS/ monograph
MedlinePlus a699052
  • US: B (No risk in non-human studies)
Pharmacokinetic data
Bioavailability <1%
Protein binding ≥99%
Half-life 12hr
80573-04-2 7pxY
PubChem CID 5362070
DrugBank DB01014 7pxY
ChemSpider 10662422 7pxY
ChEBI CHEBI:267413 7pxY
ChEMBL CHEMBL1201346 7pxN
Chemical data
Formula C17H15N3O6
357.318 g/mol
 14pxN (what is this?)  (verify)

Balsalazide is an anti-inflammatory drug used in the treatment of inflammatory bowel disease. It is sold under the brand names "Giazo", "Colazal" in the US and "Colazide" in the UK. It is also sold in generic form in the US by several generic manufacturers.

It is usually administered as the disodium salt. Balsalazide releases mesalazine, also known as 5-aminosalicylic acid, or 5-ASA,[1] in the large intestine. Its advantage over that drug in the treatment of ulcerative colitis is believed to be the delivery of the active agent past the small intestine to the large intestine, the active site of ulcerative colitis.


File:Balsalazide synthesis.png
Balsalazide synthesis: Biorex Laboratories, GB 2080796  (1986).
  1. Starting material is 4-aminohippuric acid, obtained by coupling para-aminobenzoic acid and glycine.
  2. That product is then treated with nitrous acid to give the diazonium salt.
  3. Reaction of this species with salicylic acid proceeds at the position para to the phenol to give balsalazide.


  1. ^ Kruis, W.; Schreiber, I.; Theuer, D.; Brandes, J. W.; Schütz, E.; Howaldt, S.; Krakamp, B.; Hämling, J.; Mönnikes, H.; Koop, I.; Stolte, M.; Pallant, D.; Ewald, U. (2001). "Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses". Gut 49 (6): 783–789. PMC 1728533. PMID 11709512. doi:10.1136/gut.49.6.783.  edit