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Beclamide

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Beclamide
191px
Systematic (IUPAC) name
N-benzyl-3-chloropropanamide
Clinical data
Oral
Identifiers
501-68-8 7pxY
N03AX30
PubChem CID 10391
ChemSpider 9962 7pxY
UNII F5N0ALI65V 7pxY
KEGG D07300 7pxY
ChEMBL CHEMBL64195 7pxY
Chemical data
Formula C10H12ClNO
197.661 g/mol
 14pxY (what is this?)  (verify)

Beclamide (marketed as Chloracon, Hibicon, Posedrine, Nydrane, Seclar, and other names) is a drug that possesses anticonvulsant activity.[1]

Uses

It has been used as a sedative and as an anticonvulsant.

It was studied in the 1950s for its anticonvulsant properties, as a treatment for generalised tonic-clonic seizures. It was not effective for absence seizures. It is no longer used as an AED.

Interest in the drug resumed in the 1990s for its psychiatric properties as an adjunct in the treatment of schizophrenia.[2]

Side effects

Side effects are uncommon but include stomach pain, nervousness, giddiness, skin rash and leukopenia. It is counter-indicated in breast feeding as it is passed in the milk.

Administration and pharmacology

Administration is oral, though it has an unpleasant taste. It is quickly absorbed and elimination is renal and complete within 48 hours. Beclamide is possibly metabolized to 3-chloropropanoic acid in vivo,[citation needed] which binds to the GHB receptor.

References

  1. Ahmadi M, Nicholls PJ, Smith HJ, Spencer PS, Preet-Ryatt MS, Spragg BP (October 1995). "Metabolism of beclamide after a single oral dose in man: quantitative studies". The Journal of pharmacy and pharmacology 47 (10): 876–8. PMID 8583359. doi:10.1111/j.2042-7158.1995.tb05757.x. 
  2. Raptis C, Garcia-Borreguero D, Weber MM, Dose M, Bremer D, Emrich HM (February 1990). "Anticonvulsants as adjuncts for the neuroleptic treatment of schizophrenic psychoses: a clinical study with beclamide". Acta Psychiatrica Scandinavica 81 (2): 162–7. PMID 2183543. doi:10.1111/j.1600-0447.1990.tb06472.x. 
  • The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN 0-8247-8549-5.


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