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Benactyzine

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Benactyzine
200px
Systematic (IUPAC) name
2-(diethylamino)ethyl hydroxy(diphenyl)acetate
Clinical data
AHFS/Drugs.com International Drug Names
  • (Prescription only)
Oral
Identifiers
302-40-9 7pxY
None
PubChem CID 9330
DrugBank DB09023 7pxN
ChemSpider 8966 7pxY
UNII 595EG71R3F 7pxY
KEGG D07498 7pxY
ChEMBL CHEMBL70352 7pxY
Chemical data
Formula C20H25NO3
327.417 g/mol
 14pxN (what is this?)  (verify)

Benactyzine is an anticholinergic drug that was used as an antidepressant in the treatment of depression and associated anxiety before it was pulled from the U.S. market by the FDA due to its ineffectiveness.[1]

Its use for these indications was limited by side effects such as dry mouth and nausea, and at high doses it can cause more severe symptoms such as deliriant and hallucinogenic effects.[1]

Brand names have included: Suavitil, Phebex, Phobex, Cedad, Cevanol, Deprol, Lucidil, Morcain, Nutinal, Parasan. While there was some tentative evidence when combined with meprobamate with the medication no longer available it is not clinical important.[2]

History

Benactyzine was brought to market in the US in 1957 by Merck under the tradename, Suavitil.[3]

See also

3-Quinuclidinyl benzilate

References

  1. 1.0 1.1 Shorter, E., Looking backwards: a possible new path for drug discovery in psychopharmacology. Nat Rev Drug Discov 2002, 1 (12), 1003-1006.
  2. DeBattista, Alan F. Schatzberg, Jonathan O. Cole, Charles (2010). Manual of clinical psychopharmacology (7th ed. ed.). Washington, DC: American Psychiatric Pub. p. 423. ISBN 9781585623778. 
  3. Smith, Mickey C., PhD. Principles of Pharmaceutical Marketing, Third Edition. 3rd ed. New York: Routledge, 2013. Print. ISBN 9781317940715

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