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Benzathine benzylpenicillin

Benzathine benzylpenicillin
File:Benzylpenicillin-Benzathin Structural Formula V.1.svg
Combination of
Benzylpenicillin Antibiotic
Benzathine Stabilizer
Clinical data
AHFS/ International Drug Names
1538-09-6 7pxN
PubChem CID 15232
ChemSpider 14498 7pxN
ChEBI CHEBI:51352 7pxN
ChEMBL CHEMBL1200651 7pxN
 14pxN (what is this?)  (verify)

Benzathine benzylpenicillin (rINN) is a form of penicillin also known as benzathine penicillin. It is an antibiotic useful for the treatment of a number of bacterial infections.

It is slowly absorbed into the circulation, after intramuscular injection, and hydrolysed to benzylpenicillin in vivo. It is the drug-of-choice when prolonged low concentrations of benzylpenicillin are required and appropriate, allowing prolonged antibiotic action over 2–4 weeks after a single IM dose. It is marketed by Wyeth under the trade name Bicillin L-A.

Medical uses for benzathine penicillin include: prevention of rheumatic fever and early or latent syphilis.[1]

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[2]

Adverse effects

Further information: Penicillin drug reaction

Compendial status


  1. ^ Rossi S, editor, ed. (2006). Australian Medicines Handbook. Adelaide: Australian Medicines Handbook. ISBN 0-9757919-2-3. 
  2. ^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014. 
  3. ^ British Pharmacopoeia Commission Secretariat. "Index (BP 2009)" (PDF). Retrieved 26 March 2010.