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Beraprost

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Beraprost
300px
Systematic (IUPAC) name
2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-
methyl-1-octen-6-ynyl)-1H-cyclopenta(b)benzofuran-
5-butanoic acid
Clinical data
AHFS/Drugs.com International Drug Names
  •  ?
Oral
Pharmacokinetic data
Bioavailability 50–70%
Metabolism Unknown
Half-life 35–40 minutes
Excretion ?
Identifiers
88430-50-6 7pxY 88475-69-8
B01AC19
PubChem CID 5282428
IUPHAR ligand 1967
ChemSpider 5293169 7pxY
UNII 35E3NJJ4O6 7pxY
ChEMBL CHEMBL1207745 7pxN
Chemical data
Formula C24H30O5
398.492 g/mol
 14pxN (what is this?)  (verify)

Beraprost is a synthetic analogue of prostacyclin, under clinical trial for the treatment of pulmonary hypertension. It is also being studied for use in avoiding reperfusion injury.

Clinical pharmacology

As an analogue of prostacyclin PGI2, beraprost affects vasodilation, which in turn lowers blood pressure. Beraprost also inhibits platelet aggregation, though the role this phenomenon may play in relation to pulmonary hypertension has yet to be determined.

Dosage and administration

Beraprost is administered orally as a pill.

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