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Open Access Articles- Top Results for Beta-1 adrenergic receptor

Beta-1 adrenergic receptor

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsADRB1 ; ADRB1R; B1AR; BETA1AR; RHR
External IDsOMIM109630 MGI87937 HomoloGene20171 IUPHAR: 28 ChEMBL: 213 GeneCards: ADRB1 Gene
RNA expression pattern
File:PBB GE ADRB1 208214 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez15311554
EnsemblENSG00000043591ENSMUSG00000035283
UniProtP08588P34971
RefSeq (mRNA)NM_000684NM_007419
RefSeq (protein)NP_000675NP_031445
Location (UCSC)Chr 10:
115.8 – 115.81 Mb
Chr 19:
56.72 – 56.72 Mb
PubMed search[1][2]

The beta-1 adrenergic receptor1 adrenoreceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it.[1] It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein and is expressed predominantly in cardiac tissue.

Receptor

Actions

Actions of the β1 receptor include:

Agonists

Isoprenaline has higher affinity for β1 than adrenaline, which, in turn, binds with higher affinity than noradrenaline at physiologic concentrations. Selective agonists to the beta-1 receptor are:

Antagonists

(Beta blockers) β1-selective ones are:

Mechanism

Gs renders adenylate cyclase activated, resulting in increase of cAMP.

Gene

Specific polymorphisms in the ADRB1 gene have been shown to affect the resting heart rate and can be involved in heart failure.[1]

Interactions

Beta-1 adrenergic receptor has been shown to interact with DLG4[5] and GIPC1.[6] Interaction between testosterone and β-1 ARs have been shown in anxiolytic behaviors in the basolateral amygdala.[7]

See also

References

  1. ^ a b "Entrez Gene: ADRB1 adrenergic, beta-1-, receptor". 
  2. ^ a b c d e Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4.  Page 163
  3. ^ a b c d e Fitzpatrick, David; Purves, Dale; Augustine, George (2004). "Table 20:2". Neuroscience (Third ed.). Sunderland, Mass: Sinauer. ISBN 0-87893-725-0. 
  4. ^ American Society of Health-System Pharmacists, Inc. (2005-01-01). "Bisoprolol". MedlinePlus Drug Information. U.S. National Library of Medicine, National Institutes of Health. Archived from the original on 2008-05-20. Retrieved 2008-06-06. 
  5. ^ Hu LA, Tang Y, Miller WE, Cong M, Lau AG, Lefkowitz RJ, Hall RA (2000). "beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors". J. Biol. Chem. 275 (49): 38659–66. PMID 10995758. doi:10.1074/jbc.M005938200. 
  6. ^ Hu LA, Chen W, Martin NP, Whalen EJ, Premont RT, Lefkowitz RJ (2003). "GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation". J. Biol. Chem. 278 (28): 26295–301. PMID 12724327. doi:10.1074/jbc.M212352200. 
  7. ^ Mard-Soltani M, Kesmati M, Khajehpour L, Rasekh A, Shamshirgar-Zadeh A (April 2012). "Interaction between Anxiolytic Effects of Testosterone and β-1 Adrenoceptors of Basolateral Amygdala". International Journal of Pharmacology 8 (5): 344–354. doi:10.3923/ijp.2012.344.354. 

External links

  • 1-adrenoceptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

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