Open Access Articles- Top Results for Bifemelane


Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
90293-01-9 7pxY
PubChem CID 2377
ChemSpider 2286 7pxY
UNII Z4501GN13G 7pxY
ChEMBL CHEMBL1192517 7pxN
Chemical data
Formula C18H23NO
269.381 g/mol
 14pxN (what is this?)  (verify)

Bifemelane (Alnert, Celeport) is a pharmaceutical drug used in the treatment of senile dementia in Japan.[1] It has nootropic, neuroprotective, and antidepressant effects, and acts through the cholinergic system in the brain.[2][3][4] Bifemelane is also useful for the treatment of glaucoma.[5]

See also


  1. ^ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. p. 265. ISBN 0-412-46630-9. 
  2. ^ Kondo, Y; Ogawa, N; Asanuma, M; Matsuura, K; Nishibayashi, K; Iwata, E (1996). "Preventive effects of bifemelane hydrochloride on decreased levels of muscarinic acetylcholine receptor and its mRNA in a rat model of chronic cerebral hypoperfusion". Neuroscience research 24 (4): 409–14. PMID 8861111. doi:10.1016/0168-0102(95)01017-3. 
  3. ^ Egashira, T; Takayama, F; Yamanaka, Y (1996). "Effects of bifemelane on muscarinic receptors and choline acetyltransferase in the brains of aged rats following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries". Japanese journal of pharmacology 72 (1): 57–65. PMID 8902600. doi:10.1254/jjp.72.57. 
  4. ^ Moryl E, Danysz W, Quack G (June 1993). "Potential antidepressive properties of amantadine, memantine and bifemelane". Pharmacology & Toxicology 72 (6): 394–7. PMID 8361950. doi:10.1111/j.1600-0773.1993.tb01351.x. 
  5. ^ Shigemitsu, T; Majima, Y (1996). "Use of bifemelane hydrochloride in improving and maintaining the visual field of patients with glaucoma". Clinical therapeutics 18 (1): 106–13. PMID 8851457. doi:10.1016/S0149-2918(96)80183-4. 

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