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Big dynorphin

Big dynorphin is a form of dynorphin consisting of dynorphin A and dynorphin B. It has nociceptive and anxiolytic-like properties, as well as effects on memory in mice [1] [2]

It binds to the kappa-opioid receptor.[3]


  1. ^ Kuzmin, Alexander; Madjid, Nather; Terenius, Lars; Ogren, Sven Ove; Bakalkin, Georgy (2005). "Big Dynorphin, a Prodynorphin-Derived Peptide Produces NMDA Receptor-Mediated Effects on Memory, Anxiolytic-Like and Locomotor Behavior in Mice". Neuropsychopharmacology 31 (9): 1928–1937. ISSN 0893-133X. doi:10.1038/sj.npp.1300959. 
  2. ^ Tan-No K, Esashi A, Nakagawasai O et al. (2002). "Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism". Brain Res. 952 (1): 7–14. PMID 12363399. doi:10.1016/S0006-8993(02)03180-3. 
  3. ^ Merg F, Filliol D, Usynin I et al. (2006). "Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor". J. Neurochem. 97 (1): 292–301. PMID 16515546. doi:10.1111/j.1471-4159.2006.03732.x. 


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