Bill McPherson is a former American football coach in the National Football League. He was the San Francisco 49ers defensive coordinator from 1992 to 1993. He was a coach or front office executive in the 49ers organization from 1979 to 2005 and won five Super Bowls.
McPherson was most known for his ability to coach the defensive line, serving as coach of that position for Santa Clara University (1963–1974), UCLA (1975–1977), Philadelphia Eagles (1978), and San Francisco 49ers (1979–1991, 1994–1998). While with Santa Clara, he also served as linebackers coach and associate head coach.
His son, Pat, is the tight ends coach for the Seattle Seahawks.