Open Access Articles- Top Results for Biphenylindanone A

Biphenylindanone A

Biphenylindanone A
Systematic (IUPAC) name
3’-(((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro- 1H-inden-5-yl)oxy)methyl)biphenyl-4-carboxylic acid
Clinical data
PubChem CID 9868580
ChemSpider 8044271 7pxY
ChEMBL CHEMBL593013 7pxY
Chemical data
Formula C30H30O4
454.556 g/mol
 14pxY (what is this?)  (verify)

Biphenylindanone A (BINA, LS-193,571) is a research agent which acts as a potent and selective positive allosteric modulator for the group II metabotropic glutamate receptor subtype mGluR2.

In animal studies it showed anxiolytic and antipsychotic effects,[1] and blocked the effects produced by the hallucinogenic drug DOB. BINA and other selective mGluR2 positive modulators have therefore been suggested as a novel class of drugs for the treatment of schizophrenia which may have superior properties to traditional antipsychotic drugs.[2]

BINA decreases cocaine self-administration in rats, with no effect on food self-administration, and is in regard to this discrimination superior to the mGluR2/3 agonist LY-379,268[3]


  1. ^ Galici R; Jones CK; Hemstapat K et al. (2006). "Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice". The Journal of Pharmacology and Experimental Therapeutics 318 (1): 173–85. PMID 16608916. doi:10.1124/jpet.106.102046. 
  2. ^ Benneyworth MA, Xiang Z, Smith RL, Garcia EE, Conn PJ, Sanders-Bush E (2007). "A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis". Molecular Pharmacology 72 (2): 477–84. PMID 17526600. doi:10.1124/mol.107.035170. 
  3. ^ Jin, Xinchun; Semenova, Svetlana; Yang, Li; Ardecky, Robert; Sheffler, Douglas J; Dahl, Russell; Conn, P Jeffrey; Cosford, Nicholas DP; Markou, Athina (2010). "The mGluR2 Positive Allosteric Modulator BINA Decreases Cocaine Self-Administration and Cue-Induced Cocaine-Seeking and Counteracts Cocaine-Induced Enhancement of Brain Reward Function in Rats". Neuropsychopharmacology 35 (10): 2021–36. PMC 2922422. PMID 20555310. doi:10.1038/npp.2010.82. 

Lua error in package.lua at line 80: module 'Module:Buffer' not found.