Open Access Articles- Top Results for Blister


For other uses, see Blister (disambiguation).
For the term "vesiculation" as used in geology, see vesicular texture.
Blister on foot caused by friction.
Classification and external resources
ICD-10 T14.0
ICD-9 919.2
DiseasesDB 1777
MedlinePlus 003239
NCI Blister
Patient UK Blister
MeSH D001768

A blister is a small pocket of fluid within the upper layers of the skin, typically caused by forceful rubbing (friction), burning, freezing, chemical exposure or infection. Most blisters are filled with a clear fluid called serum or plasma.[1] However, blisters can be filled with blood (known as blood blisters) or with pus (if they become infected).

The word "blister" entered English in the 14th century. It came from the Middle Dutch "bluyster", and was a modification of the Old French "blostre" which meant a leprous nodule—a rise in the skin due to leprosy.


A blister may form when the skin has been damaged by friction or rubbing, heat, cold or chemical exposure. Fluid collects between the epidermis—the upper layer of the skin—and the layers below. This fluid cushions the tissue underneath, protecting it from further damage and allowing it to heal.

Friction or rubbing

File:Friction Blisters On Human Foot.jpg
Picture of various size blisters on the sole of a foot due to friction.

Intense rubbing can cause a blister, as can any friction on the skin if continued long enough. This kind of blister is most common after walking long distances or by wearing old or poorly fitting shoes.[2][3][4] Blisters are most common on the hands and feet, as these extremities are susceptible while walking, running, or performing repetitive motions. Blisters form more easily on moist skin than on dry or soaked skin,[5] and are more common in warm conditions. Less-aggressive rubbing over long periods of time may cause calluses to form rather than a blister. Both blisters and calluses can lead to more serious complications, such as foot ulceration and infection, particularly when sensation or circulation is impaired, as in the case of diabetes, neuropathy or peripheral artery disease (PAD).

Extreme temperature

A blister caused by burning.

The time of blistering is one of the tools used to determine the degree of burns sustained. First and second degree burns may result in blistered skin; however, it is characteristic of second degree burns to blister immediately, whereas first degree burns can have blisters after a couple of days. Blisters can also form on the hands and feet as a result of tissue damage incurred by frostbite.[6]

Chemical exposure

Blisters caused by chemical exposure.

Sometimes, the skin will blister when it comes into contact with a cosmetic, detergent, solvent, or other chemical such as nickel sulfate or Balsam of Peru.[7] This is known as contact dermatitis. Blisters can also develop as a result of an allergic reaction to an insect bite or sting. Some chemical warfare agents, known as blister agents or vesicants, cause large, painful blisters wherever they contact skin; an example is mustard gas.


A blood blister usually forms when a minute blood vessel close to the surface of the skin ruptures (breaks) and blood leaks into a tear between the layers of skin. This can happen if the skin is crushed, pinched or aggressively squeezed.

Medical conditions

There are also a number of medical conditions that cause blisters. The most common are chickenpox, herpes, impetigo, and a form of eczema called dyshidrosis. Other, much rarer conditions that cause blisters include:

  • Bullous pemphigoid: a skin disease that causes large, tightly filled blisters to develop, usually affecting people over the age of 60.
  • Pemphigus: a serious skin disease in which blisters develop if pressure is applied to the skin; the blisters burst easily, leaving raw areas that can become infected.
  • Dermatitis herpetiformis: a skin disease that causes intensely itchy blisters, usually on the elbows, knees, back and buttocks. The blisters usually develop in patches of the same shape and size on both sides of the body.
  • Chronic bullous dermatosis: a disease that causes clusters of blisters on the face, mouth or genitals.
  • Cutaneous radiation syndrome
  • Epidermolysis Bullosa


Friction blisters

Friction blisters, caused by rubbing against the skin, can be prevented by reducing the friction to a level where blisters will not form.[2][3][4][8] This can be accomplished in a variety of ways.

Blisters on the feet can be prevented by wearing comfortable, well-fitting shoes and clean socks. Inherently ill-fitting or stiffer shoes, such as high heels and dress shoes, present a larger risk of blistering. Blisters are more likely to develop on skin that is moist, so socks that manage moisture or frequent sock changes will aid those with particularly sweaty feet. While exercising or playing sports, special sports socks can help keep feet drier and reduce the chance of blisters.[9] Before going for a long walk, it is also important to ensure that shoes or hiking boots have been properly broken in.

Even before a "hot" or irritated area on the foot is felt, taping a protective layer of padding or a friction-reducing interface between the affected area and the footwear can prevent the formation of a blister.[10] Bandages, moleskin and tapes generally must be applied to the foot daily, and most have a very high coefficient of friction (COF), but a friction-management patch applied to the shoe will remain in place much longer, throughout many changes of socks and insoles. This type of intervention may be used with footwear that is worn daily, with specialty shoes and boots like hockey skates, ice skates, inline skates, ski boots and cleats, or even with orthotic braces and splints.

To avoid friction blisters on the hands, gloves should be worn when using tools such as a shovel or pickaxe, doing manual work such as gardening, or using sports equipment like golf clubs or baseball bats. Oars used for competitive rowing are known for causing frequent blisters on the hands of oarsmen. Weightlifters are also prone to blisters as are gymnasts from the friction developed by the rubbing against the bars. To further reduce the occurrence one can tape the hands, and there are also a number of products on the market that claim to reduce the occurrence of blisters. These are all intended to be worn as a liner underneath a glove. The majority of these offerings simply add padding and create a layer that reduces the coefficient of friction between the skin and the glove.

A lubricant, typically talcum powder, can be used to reduce friction between skin and apparel in the short term. People put talcum powder inside gloves or shoes for this purpose, although this type of lubricant will increase the friction in the long term, as it absorbs moisture. Increased friction makes blisters more likely.


Sunscreen and protective clothing should also be used during the hottest part of the day to avoid blisters from sunburn. Avoiding sunlight during midday is the best way to avoid blisters from sunburn. Protective gloves should be worn when handling detergents, cleaning products, solvents and other chemicals.


Friction blisters

File:Foot blister.jpg
Larger blister on foot three days after treatment with tincture of benzoin

Friction blisters are caused by excess shear stress between the surface of the skin and the body. The strata of skin around the Stratum spinosum are most susceptible to shear. As the Stratum spinosum tears away from the connecting tissues below, plasma from the cells diffuses out. This plasma solution helps new cells divide and grow into new connective tissues and epidermal layers.

The clear fluid will be reabsorbed as new cells develop and the swollen appearance will subside. The time for blisters to heal depends on the location and the size of the area damaged. Protecting the blister from abrasion or additional shearing will help keep the blister intact.

Painful blisters located on hands (palmar surface) and feet (plantar surface) are due to tissue shearing deeper in the epidermis, near nerve endings. Lower tissues are more susceptible to infection.

Blisters can occasionally become infected. Infection should be prevented with good hygiene practices, and treated if necessary. There is heightened concern about MRSA and other kinds of infections from blisters, so they should be watched carefully.

Blisters due to sunburn

Most of these blisters will heal naturally. Immediate relief from a burn blister may be found by placing the affected area in cold water. Avoid ice as it may further damage skin. Moisturizing and after-sun or calamine lotions can help to ease discomfort in the case of burns. Over-the-counter pain medications, such as ibuprofen or tylenol may provide some relief. Make sure to hydrate and drink plenty of fluids while the burn is healing. Avoid additional sun exposure while the burn in healing.

Seek Medical attention if: The sunburn covers a large portion of your body such as the entire back. The sunburn is accompanied by a high fever or severe pain. A skin infection develops. The burn doesn't begin to improve within a few days.

Your doctor might suggest a corticosteroid cream for your sunburn, or a short course of prednisone for severe cases involving large areas of your body. Rarely, people who have severe sunburn may need intravenous fluids to combat dehydration.[11]

See also


  1. ^ Uchinuma, E; Koganei, Y; Shioya, N; Yoshizato, K (1988). "Biological evaluation of burn blister fluid". Annals of plastic surgery 20 (3): 225–30. PMID 3358612. doi:10.1097/00000637-198803000-00005. 
  2. ^ a b [Naylor PFD. "The Skin Surface and Friction," British Journal of Dermatology. 1955;67:239–248.]
  3. ^ a b [Naylor PFD. "Experimental Friction Blisters," British Journal of Dermatology. 1955;67:327–342.]
  4. ^ a b [Sulzberger MB, Cortese TA, Fishman L, Wiley HS. "Studies on Blisters Produced by Friction," Journal of Investigative Dermatology. 1966;47:456–465.]
  5. ^ [Carlson JM. "The Friction Factor," OrthoKinetic Review. Nov/Dec 2001;1(7):1–3.]
  6. ^ "First Degree Burns". Retrieved 2012-02-21. 
  7. ^ Conn's Current Therapy 2011: Expert Consult - Edward T. Bope, Rick D. Kellerman, Robert E. Rakel - Google Books
  8. ^ [Hanna T, Carlson JM. "Freedom from Friction," OrthoKinetic Review. Mar/Apr 2004;4(2):34–35.]
  9. ^ "Treatment Skin Blisters – Blister On Bottom Of Foot – Blister On Foot". Retrieved 2012-02-21. 
  10. ^ Adventure Medical Kit Blister Medic Gel -
  11. ^

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