Open Access Articles- Top Results for Blue nails

Blue nails

Azure Lunula
Classification and external resources
DiseasesDB 1513
NCI Blue nails
Patient UK Blue nails

Blue nails, or more formally azure lunula, are characterized by a blue discoloration of the lunulae, seen in argyria and cases of hepatolenticular degeneration (Wilson's disease), also having been reported in hemoglobin M disease and hereditary acrolabial telangiectases.[1]

In Wilson's disease the blue color involves the lunula (most intense pigmentation) and fades proximally. In argyria, the nail is permanently pigmented a slate-blue color and is most evident in the lunula. Minocycline can also turn the nail plate blue-gray.[2]


In season 6 of House MD in the episode 11 titled Remorse, House diagnoses his patient with Wilson's Disease in absence of Kayser-Fleischer rings by removing the nail polish to note the blue nails.

See also


  1. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  2. ^ Tosti A, Iorizzo M, Piraccini BM, Starace M (July 2006). "The nail in systemic diseases". Dermatol Clin 24 (3): 341–7. PMID 16798431. doi:10.1016/j.det.2006.03.005.