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Bradykinin receptor B1

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsBDKRB1 ; B1BKR; B1R; BKB1R; BKR1; BRADYB1
External IDsOMIM600337 MGI88144 HomoloGene570 IUPHAR: 41 ChEMBL: 4308 GeneCards: BDKRB1 Gene
RNA expression pattern
File:PBB GE BDKRB1 207510 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez62312061
EnsemblENSG00000100739ENSMUSG00000041347
UniProtP46663Q61125
RefSeq (mRNA)NM_000710NM_007539
RefSeq (protein)NP_000701NP_031565
Location (UCSC)Chr 14:
96.72 – 96.74 Mb
Chr 12:
105.6 – 105.61 Mb
PubMed search[1][2]

Bradykinin receptor B1 (B1) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. Its principal ligand is bradykinin, a 9 amino acid peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The B1 receptor is one of two of G protein-coupled receptors that have been found which bind bradykinin and mediate responses to these pathophysiologic conditions.

B1 protein is synthesized de novo following tissue injury and receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.[1]

Classical agonist of this receptor includes bradykinin1-8 (bradykinin with the first 8 amino acid) and antagonist includes [Leu8]-bradykinin1-8.[2]

Antagonists

See also

References

External links

  • "Bradykinin Receptors: B1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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