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Open Access Articles- Top Results for Brain-specific angiogenesis inhibitor 1

Brain-specific angiogenesis inhibitor 1

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsBAI1 ; GDAIF
External IDsOMIM602682 MGI1933736 HomoloGene1287 IUPHAR: 174 GeneCards: BAI1 Gene
RNA expression pattern
File:PBB GE BAI1 206083 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez575107831
EnsemblENSG00000181790ENSMUSG00000034730
UniProtO14514Q3UHD1
RefSeq (mRNA)NM_001702NM_174991
RefSeq (protein)NP_001693NP_778156
Location (UCSC)Chr 8:
143.53 – 143.63 Mb
Chr 15:
74.52 – 74.59 Mb
PubMed search[1][2]

Brain-specific angiogenesis inhibitor 1 is a protein that in humans is encoded by the BAI1 gene.[1][2] It is a member of the adhesion-GPCR family of receptors.[3]

Function

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.[2]

Interactions

Brain-specific angiogenesis inhibitor 1 has been shown to interact with BAIAP3[4] and MAGI1.[5]

Model organisms

Model organisms have been used in the study of BAI1 function. A conditional knockout mouse line called Bai1tm2a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[6] Male and female animals underwent a standardized phenotypic screen[7] to determine the effects of deletion.[8][9][10][11] Additional screens performed: - In-depth immunological phenotyping[12] - in-depth bone and cartilage phenotyping[13]

References

  1. ^ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenetics and Cell Genetics 79 (1-2): 103–8. PMID 9533023. doi:10.1159/000134693. 
  2. ^ a b "Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1". 
  3. ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  4. ^ Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T et al. (Oct 1998). "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications 251 (1): 158–65. PMID 9790924. doi:10.1006/bbrc.1998.9408. 
  5. ^ Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T (Jun 1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications 247 (3): 597–604. PMID 9647739. doi:10.1006/bbrc.1998.8603. 
  6. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  7. ^ a b "International Mouse Phenotyping Consortium". 
  8. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337â€"42. PMC 3572410. PMID 21677750. doi:10.1038/nature10163. 
  9. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a. 
  10. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9â€"13. PMID 17218247. doi:10.1016/j.cell.2006.12.018. 
  11. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. PMID 23870131. doi:10.1016/j.cell.2013.06.022. 
  12. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 
  13. ^ a b "OBCD Consortium". 

Further reading

  • Van Meir EG, Polverini PJ, Chazin VR, Su Huang HJ, de Tribolet N, Cavenee WK (Oct 1994). "Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells". Nature Genetics 8 (2): 171–6. PMID 7531056. doi:10.1038/ng1094-171. 
  • Nishimori H, Shiratsuchi T, Urano T, Kimura Y, Kiyono K, Tatsumi K et al. (Oct 1997). "A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis". Oncogene 15 (18): 2145–50. PMID 9393972. doi:10.1038/sj.onc.1201542. 
  • Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T (Jun 1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications 247 (3): 597–604. PMID 9647739. doi:10.1006/bbrc.1998.8603. 
  • Fukushima Y, Oshika Y, Tsuchida T, Tokunaga T, Hatanaka H, Kijima H et al. (Nov 1998). "Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer". International Journal of Oncology 13 (5): 967–70. PMID 9772287. doi:10.3892/ijo.13.5.967. 
  • Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T et al. (Oct 1998). "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications 251 (1): 158–65. PMID 9790924. doi:10.1006/bbrc.1998.9408. 
  • Oda K, Shiratsuchi T, Nishimori H, Inazawa J, Yoshikawa H, Taketani Y et al. (1999). "Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1". Cytogenetics and Cell Genetics 84 (1-2): 75–82. PMID 10343108. doi:10.1159/000015219. 
  • Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q et al. (Jul 2000). "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase". The Journal of Biological Chemistry 275 (28): 21477–85. PMID 10748157. doi:10.1074/jbc.M909741199. 
  • Koh JT, Lee ZH, Ahn KY, Kim JK, Bae CS, Kim HH et al. (Mar 2001). "Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein". Brain Research. Molecular Brain Research 87 (2): 223–37. PMID 11245925. doi:10.1016/S0169-328X(01)00004-3. 
  • Duda DG, Sunamura M, Lozonschi L, Yokoyama T, Yatsuoka T, Motoi F et al. (Feb 2002). "Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis". British Journal of Cancer 86 (3): 490–6. PMC 2375213. PMID 11875720. doi:10.1038/sj.bjc.6600067. 
  • Lim IA, Hall DD, Hell JW (Jun 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". The Journal of Biological Chemistry 277 (24): 21697–711. PMID 11937501. doi:10.1074/jbc.M112339200. 
  • Mori K, Kanemura Y, Fujikawa H, Nakano A, Ikemoto H, Ozaki I et al. (May 2002). "Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells". Neuroscience Research 43 (1): 69–74. PMID 12074842. doi:10.1016/S0168-0102(02)00018-4. 
  • Kaur B, Brat DJ, Calkins CC, Van Meir EG (Jan 2003). "Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression". The American Journal of Pathology 162 (1): 19–27. PMC 1851137. PMID 12507886. doi:10.1016/S0002-9440(10)63794-7. 
  • Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD et al. (Dec 2002). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Molecular & Cellular Proteomics 1 (12): 947–55. PMID 12543931. doi:10.1074/mcp.M200066-MCP200. 
  • Koh JT, Kook H, Kee HJ, Seo YW, Jeong BC, Lee JH et al. (Mar 2004). "Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin". Experimental Cell Research 294 (1): 172–84. PMID 14980512. doi:10.1016/j.yexcr.2003.11.008. 
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics 84 (1): 23–33. PMID 15203201. doi:10.1016/j.ygeno.2003.12.004. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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