Brain death

For the EP by Nuclear Assault, see Brain Death (EP).
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Brain dead
Classification and external resources
ICD-9 348.82
DiseasesDB 1572
NCI Brain death
Patient UK Brain death
MeSH D001926

Brain death is the complete and irreversible loss of brain function (including involuntary activity necessary to sustain life).[1][2][3][4] Brain death is one of the two ways of determination of death, according to the Uniform Determination of Death Act of the United States (the other way of determining death being "irreversible cessation of circulatory and respiratory functions").[5] It is not the same as persistent vegetative state, in which the person is "alive".

Brain death is used as an indicator of legal death in many jurisdictions, but it is defined inconsistently. Various parts of the brain may keep living when others die, and the term "brain death" has been used to refer to various combinations. For example, although a major medical dictionary[which?] says that "brain death" is synonymous with "cerebral death" (death of the cerebrum), the US National Library of Medicine Medical Subject Headings (MeSH) system defines brain death as including the brainstem. The distinctions can be important because, for example, in someone with a dead cerebrum but a living brainstem, the heartbeat and ventilation can continue unaided, whereas in whole-brain death (which includes brain stem death), only life support equipment would keep those functions going. Patients classified as brain-dead can have their organs surgically removed for organ donation; though not everyone agrees with this practice, preferring to limit organ donation to those individuals who have suffered the death of all of their brain and the death of their cardiac and respiratory systems (biological, or full, death). However, if one limits the criteria to those individuals, procuring viable organs can become much more difficult.

Legal history

Traditionally, both the legal and medical communities determined death through the permanent end of certain bodily functions in clinical death, especially respiration and heartbeat. With the increasing ability of the medical community to resuscitate people with no respiration, heartbeat, or other external signs of life, the need for another definition of death occurred, raising questions of legal death. This gained greater urgency with the widespread use of life support equipment, as well as rising capabilities and demand for organ transplantation.

Since the 1960s, laws on determining death have, therefore, been implemented in all countries with active organ transplantation programs. The first European country to adopt brain death as a legal definition (or indicator) of death was Finland, in 1971. In the United States, Kansas had enacted a similar law earlier.[6] In the 1970s, the Supreme Court of the state of New Jersey ruled that patients and their families have the right to decide when and whether to remove life support.[7]

An ad hoc committee at Harvard Medical School published a pivotal 1968 report to define irreversible coma.[8][9] The Harvard criteria gradually gained consensus toward what is now known as brain death. In the wake of the 1976 Karen Ann Quinlan controversy, state legislatures in the United States moved to accept brain death as an acceptable indication of death. In 1981 a Presidential commission issued a landmark report – Defining Death: Medical, Legal, and Ethical Issues in the Determination of Death [10] – that rejected the "higher brain" approach to death in favor of a "whole brain" definition. This report was the basis for the Uniform Determination of Death Act, which has been enacted in 39 states of the United States[11] the Uniform Determination of Death Act in the United States attempts to standardize criteria. Today, both the legal and medical communities in the US use "brain death" as a legal definition of death, allowing a person to be declared legally dead even if life support equipment keeps the body's metabolic processes working.

In the UK, the Royal College of Physicians reported in 1995, abandoning the 1979 claim that the tests published in 1976 sufficed for the diagnosis of brain death and suggesting a new definition of death based on the irreversible loss of brain stem function alone.[12] This new definition, the irreversible loss of the capacity for consciousness and for spontaneous breathing, and the essentially unchanged 1976 tests held to establish that state, have been adopted as a basis of death certification for organ transplant purposes in subsequent Codes of Practice.[13]

Medical criteria

A brain-dead individual has no clinical evidence of brain function upon physical examination. This includes no response to pain and no cranial nerve reflexes. Reflexes include pupillary response (fixed pupils), oculocephalic reflex, corneal reflex, no response to the caloric reflex test, and no spontaneous respirations.

It is important to distinguish between brain death and states that may be difficult to differentiate from brain death (such as barbiturate overdose, alcohol intoxication, sedative overdose, hypothermia, hypoglycemia, coma, and chronic vegetative states). Some comatose patients can recover to pre-coma or near pre-coma level of functioning, and some patients with severe irreversible neurological dysfunction will nonetheless retain some lower brain functions such as spontaneous respiration, despite the losses of both cortex and brain stem functionality; such is the case with anencephaly.

Note that brain electrical activity can stop completely, or drop to such a low level as to be undetectable with most equipment. An EEG will therefore be flat, though this is sometimes also observed during deep anesthesia or cardiac arrest.[14] Although in the United States a flat EEG test is not required to certify death, it is considered to have confirmatory value. In the UK it is not considered to be of value because any continuing activity it might reveal in parts of the brain above the brain stem is held to be irrelevant to the diagnosis of death on the Code of Practice criteria.[15]

The diagnosis of brain death needs to be rigorous, in order to be certain that the condition is irreversible. Legal criteria vary, but in general they require neurological examinations by two independent physicians. The exams must show complete and irreversible absence of brain function (brain stem function in UK),[16] and may include two isoelectric (flat-line) EEGs 24 hours apart (less in other countries where it is accepted that if the cause of the dysfunction is a clear physical trauma there is no need to wait that long to establish irreversibility). The patient should have a normal temperature and be free of drugs that can suppress brain activity if the diagnosis is to be made on EEG criteria.

File:Radionuclide Cerebral Blood Flow Scan.png
Radionuclide scan: No intracranial blood flow and "hot-nose" sign.

Also, a radionuclide cerebral blood flow scan that shows complete absence of intracranial blood flow must be considered with other exams – temporary swelling of the brain, particularly within the first 72 hours, can lead to a false positive test on a patient that may recover with more time.[17] Zack Dunlap in 2008 had a false positive of this type, likely due to temporary cerebral edema.

CT angiography is neither required nor sufficient test to make the diagnosis.[18]

Organ donation

Main article: Organ donation

While the diagnosis of brain death has become accepted as a basis for the certification of death for legal purposes, it should be clearly understood that it is a very different state from biological death - the state universally recognized and understood as death.[19] The continuing function of vital organs in the bodies of those diagnosed brain dead, if mechanical ventilation and other life-support measures are continued, provides optimal opportunities for their transplantation.

When mechanical ventilation is used to support the body of a brain dead organ donor pending a transplant into an organ recipient, the donor's date of death is listed as the date that brain death was diagnosed.[20]

In some countries (for instance, Spain,[21] Poland, Wales, Portugal, and France), everyone is automatically an organ donor after diagnosis of death on legally accepted criteria, although some jurisdictions (such as Singapore, Spain, Wales, France, Czech Republic and Portugal) allow opting out of the system. Elsewhere, consent from family members or next-of-kin may be required for organ donation. In New Zealand, Australia, United Kingdom (excluding Wales) and most states in the United States, drivers are asked upon application if they wish to be registered as an organ donor.[22]

In the United States, if the patient is at or near death, the hospital must notify a transplant organization of the person's details and maintain the patient while the patient is being evaluated for suitability as a donor.[23] The patient is kept on ventilator support until the organs have been surgically removed. If the patient has indicated in an advance health care directive that they do not wish to receive mechanical ventilation or has specified a do not resuscitate order and the patient has also indicated that they wish to donate their organs, some vital organs such as the heart and lungs may not be able to be recovered.[24]

See also


  1. ^ "Brain death". Encyclopedia of Death and Dying. Retrieved 25 March 2014. 
  2. ^ Young, G Bryan. "Diagnosis of brain death". UpToDate. Retrieved 25 March 2014. 
  3. ^ Goila, A.; Pawar, M. (2009). "The diagnosis of brain death". Indian Journal of Critical Care Medicine 13 (1): 7–11. PMC 2772257. PMID 19881172. doi:10.4103/0972-5229.53108.  edit
  4. ^ Machado, C. (2010). "Diagnosis of brain death". Neurology International 2. doi:10.4081/ni.2010.e2.  edit
  5. ^ "Uniform Determination of Death Act" (PDF). National Conference of Commissioners on Uniform State Laws. Retrieved 26 March 2014. 
  6. ^ (Randell T. (2004). "Medical and legal considerations of brain death". Acta Anaesthesiologica Scandinavica 48 (2): 139–144. PMID 14995934. doi:10.1111/j.0001-5172.2004.00304.x. 
  7. ^ Epstein, Sue (April 28, 2010). "N.J. court to rule whether hospitals may refuse life support despite wishes of families, patients". Retrieved March 5, 2014. 
  8. ^ "A definition of irreversible coma: report of the Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death". JAMA 205: 337–40. 1968. doi:10.1001/jama.1968.03140320031009. 
  9. ^ Life-sustaining Technologies and the Elderly
  10. ^ "Defining death: a report on the medical, legal and ethical issues in the determination of death". 
  11. ^ "Legislative Fact Sheet – Determination of Death Act". Uniform Law Commission. Retrieved 8 May 2012. 
  12. ^ Criteria for the diagnosis of brain stem death. J Roy Coll Physns of London 1995;29:381-2
  13. ^ A Code of Practice for the Diagnosis and Confirmation of Death. Academy of Medical Royal Colleges. 70 Wimpole Street, London, 2008
  14. ^ Karasawa, H et al. (Jan 2001). "Intracranial electroencephalographic changes in deep anesthesia". Clin Neurophysiol 112 (1): 25–30. PMID 11137657. doi:10.1016/s1388-2457(00)00510-1. 
  15. ^ A Code of Practice for the Diagnosis of Death. Academy of Medical Royal Colleges, 70 Wimpole Street, London, 2008
  16. ^ Waters, C. E.; French, G.; Burt, M. "Difficulty in brainstem death testing in the presence of high spinal cord injury". British Journal of Anaesthesia 92 (5): 762. doi:10.1093/bja/aeh117. 
  17. ^
  18. ^ Taylor, T; Dineen, RA; Gardiner, DC; Buss, CH; Howatson, A; Pace, NL (Mar 31, 2014). "Computed tomography (CT) angiography for confirmation of the clinical diagnosis of brain death.". The Cochrane database of systematic reviews 3: CD009694. PMID 24683063. doi:10.1002/14651858.CD009694.pub2. 
  19. ^ Truog RD, Miller FG. The meaning of brain death. JAMA Internal Medicine 2014, Publ online June 9, 2014 :
  20. ^ "Understanding Brain Death". What is the legal time of death for a brain dead patient? The legal time of death is the date and time that doctors determine that all brain activity has ceased. This is the time that is noted on the patient’s death certificate. 
  21. ^ Organización Nacional de Transplantes – Consentimiento familiar y donación
  22. ^ "National Donate Life America Donor Designation State Report Card 2013" (PDF). pp. 6 & 7. 2012 State Comparisons 
  23. ^ "State and Federal Law on Organ Procurement". Unless the individual expressed contrary intent, a hospital must take measures to ensure the medical suitability of an individual at or near death while a procurement organization examines the patient for suitability as a donor. 
  24. ^ "Frequently Asked Questions About Donation". DNR will be honored. You can still be a tissue donor. 

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