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Brallobarbital

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Brallobarbital
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Systematic (IUPAC) name
5-(2-Bromoprop-2-en-1-yl)-5-(prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
Clinical data
Identifiers
561-86-4 7pxY
None
PubChem CID 68416
ChemSpider 61699 7pxY
UNII D0N7A2M3MU 7pxY
ChEMBL CHEMBL2106093 7pxN
Synonyms Brallobarbital
Chemical data
Formula C10H11BrN2O3
287.110 g/mol
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Brallobarbital is a barbiturate developed in the 1920s.[1] It has sedative and hypnotic properties, and was used for the treatment of insomnia. Brallobarbital was primarily sold as part of a combination product called Vesparax, composed of 150 mg secobarbital, 50 mg brallobarbital and 50 mg hydroxyzine.[2] The long half-life of this combination of drugs tended to cause a hangover effect the next day,[3] and Vesparax fell into disuse once newer drugs with lesser side effects had been developed.[4]

References

  1. ^ US Patent 1869666
  2. ^ Lhermann J. Clinical application of a new very active hypnotic associating sodium secobarbital, calcium brallobarbital and hydroxyzine (UC-8130). Gazette Medicale de France. 1964 Mar 10;71:961-2. (French)
  3. ^ Yih TD, Rossum JM. Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication. Xenobiotica. 1976 Jun;6(6):355-62.
  4. ^ Fischbach R. Efficacy and safety of midazolam and vesparax in treatment of sleep disorders. British Journal of Clinical Pharmacology. 1983;16 Suppl 1:167S-171S.



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