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Open Access Articles- Top Results for Buclizine

Buclizine

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Buclizine
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Systematic (IUPAC) name
(RS)-1-[(4-chlorophenyl)- phenyl-methyl]-4- [(4-tert-butylphenyl) methyl] piperazine
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Identifiers
82-95-1 7pxY
R06AE01
PubChem CID 6729
DrugBank DB00354 7pxY
ChemSpider 6473 7pxY
UNII 0C94V6X681 7pxY
ChEBI CHEBI:3205 7pxY
ChEMBL CHEMBL1201271 7pxN
Chemical data
Formula C28H33ClN2
433.028 g/mol
 14pxN (what is this?)  (verify)

Buclizine is an antihistamine and anticholinergic of the piperazine derivative family. It is considered to be an antiemetic, similar to meclizine.[1]

In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare at migraine sufferers.[2]

References

  1. ^ Mostafa, G. A. E.; Al-Badr, A. A. (2011). "Buclizine". Profiles of drug substances, excipients, and related methodology. Profiles of Drug Substances, Excipients and Related Methodology 36: 1–33. ISBN 9780123876676. PMID 22469258. doi:10.1016/B978-0-12-387667-6.00001-4.  edit
  2. ^ Behrendt, W. A.; Cserepes, J. (1985). "Acute toxicity and analgesic action of a combination of buclizine, codeine and paracetamol ('Migraleve') in tablet and suppository form in rats". Pharmatherapeutica 4 (5): 322–331. PMID 4070325.  edit

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