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Open Access Articles- Top Results for Bufotenidine

Bufotenidine

Bufotenidine
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IUPAC name
3-[2-(Trimethylazaniumyl)ethyl]-1H-indol-5-olate
Other names
Bufotenidin
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C13H18N2O
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Bufotenidine, also known as 5-hydroxy-N,N,N-trimethyltryptammonium (5-HTQ), is a toxin related to bufotenin, serotonin, and other tryptamines which is found in the venom of a variety of toads.[1][2] It acts as a selective 5-HT3 receptor agonist, and has been used in scientific research to study the function of the 5-HT3 receptor, though this use has been limited by the fact that, as a quaternary amine, it is unable to readily cross the blood-brain-barrier..[3]

See also

References

  1. ^ Wieland, Heinrich; Konz, Wilhelm; Mittasch, Heinz (1934). "Toad poisons. VII. Constitution of bufotenin and bufotenidine". Justus Liebigs Annalen der Chemie 513: 1–25. doi:10.1002/jlac.19345130102. 
  2. ^ Raymond-Hamet (1943). "Bufotenidine, an extremely active principle of the venom of the common toad (Bufo bufo)". Comptes rendus des séances de la Société de biologie et de ses filiales 137: 74–75. 
  3. ^ Bryan L. Roth (17 August 2008). The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics. Springer Science & Business Media. pp. 108–. ISBN 978-1-59745-080-5. 



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