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Bunazosin

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Bunazosin
File:Bunazosin.png
Systematic (IUPAC) name
1-(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl)butan-1-one
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
80755-51-7
None
PubChem CID 2472
ChemSpider 2378 7pxY
UNII 9UUW4V7G2H 7pxY
ChEMBL CHEMBL188185 7pxY
Chemical data
Formula C19H27N5O3
373.44 g/mol
 14pxY (what is this?)  (verify)

Bunazosin (INN) is an alpha 1 antagonist. Bunazosin was initially developed to treat benign prostatic hyperplasia (BPH). It has been approved in Japan in a topical form to treat glaucoma. The mechanism of action is a reduction of aqueous outflow through the uveoscleral pathway resulting in lowering the intraocular pressure. It also may act to improve blood flow to the ocular nerve. Systemic Alpha-1 adrenergic receptor antagonists have been implicated in Intraoperative Floppy Iris Syndrome (IFIS). Bunazosin potentially could have the same effect but there has been no research to substantiate this as a risk for cataract surgery.


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