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Burimamide

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Burimamide
Skeletal formula
Space-filling model
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IUPAC name
1-[4-(1H-Imidazol-5-yl)butyl] -3-methylthiourea
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34970-69-9 7pxY
ChEMBL ChEMBL12160 7pxY
ChemSpider 2297780 7pxY
Jmol-3D images Image
KEGG C07448 7pxY
PubChem Template:Chembox PubChem/format
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C9H16N4S
Molar mass 212.32 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Burimamide is an antagonist at the H2 and H3 histamine receptors. It is largely inactive as an H2 antagonist at physiological pH,[1] but its H3 affinity is 100x higher. It is a thiourea derivative.

Burimamide was first developed by scientists at Smith, Kline & French (SK&F; now GlaxoSmithKline) in their intent to develop a histamine antagonist for the treatment of peptic ulcers.[2] The discovery of burimamide ultimately led to the development of cimetidine (Tagamet).[2]

See also

References

  1. Clayden, Jonathan; Greeves, Nick; Warren, Stuart; Wothers, Peter (2001). Organic Chemistry (1st ed.). Oxford University Press. p. 205. ISBN 978-0-19-850346-0. 
  2. 2.0 2.1 "Tagamet®: Discovery of Histamine H2-receptor Antagonists". National Historic Chemical Landmarks. American Chemical Society. Retrieved June 25, 2012. 

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