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Open Access Articles- Top Results for C-C chemokine receptor type 6

C-C chemokine receptor type 6

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Identifiers
SymbolsCCR6 ; BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CD196; CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; STRL22
External IDsOMIM601835 MGI1333797 HomoloGene3214 IUPHAR: 63 ChEMBL: 4423 GeneCards: CCR6 Gene
Orthologs
SpeciesHumanMouse
Entrez123512458
EnsemblENSG00000112486ENSMUSG00000040899
UniProtP51684O54689
RefSeq (mRNA)NM_004367NM_001190333
RefSeq (protein)NP_004358NP_001177262
Location (UCSC)Chr 6:
167.53 – 167.55 Mb
Chr 17:
8.24 – 8.26 Mb
PubMed search[1][2]

Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene.[1] CCR6 has also recently been designated CD196 (cluster of differentiation 196).

Function

This protein belongs to family A of G protein-coupled receptor superfamily. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dendritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.[2]

Molecular biology

The gene is located on the long arm of Chromosome 6 (6q27) on the Watson (plus) strand. It is 139,737 bases long and encodes a protein of 374 amino acids (molecular weight 42,494 Da).[1]

Clinical significance

CCR6 has been associated with Crohn's disease.[3] Expression of CCR6 was found to be up-regulated in colorectal cancer. Novel researches identified microRNA that is able to downregulate CCR6 in cancer cell lines. [4]

References

  1. ^ a b Zaballos A, Varona R, Gutiérrez J, Lind P, Márquez G (October 1996). "Molecular cloning and RNA expression of two new human chemokine receptor-like genes". Biochem. Biophys. Res. Commun. 227 (3): 846–53. PMID 8886020. doi:10.1006/bbrc.1996.1595. 
  2. ^ "Entrez Gene: CCR6 chemokine (C-C motif) receptor 6". 
  3. ^ Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, Sleiman PM, Imielinski M, Glessner J, Hou C, Wilson DC, Walters T, Kim C, Frackelton EC, Lionetti P, Barabino A, Van Limbergen J, Guthery S, Denson L, Piccoli D, Li M, Dubinsky M, Silverberg M, Griffiths A, Grant SF, Satsangi J, Baldassano R, Hakonarson H (February 2009). "Diverse Genome-wide Association Studies Associate the IL12/IL23 Pathway with Crohn Disease". Am. J. Hum. Genet. 84 (3): 399–405. PMC 2668006. PMID 19249008. doi:10.1016/j.ajhg.2009.01.026. 
  4. ^ Rubie C (Feb 2014). "Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells.". J Transl Med. 12. PMID 24559209. doi:10.1186/1479-5876-12-48. 

External links

  • "Chemokine Receptors: CCR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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