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CACNA2D1

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Identifiers
SymbolsCACNA2D1 ; CACNA2; CACNL2A; CCHL2A; LINC01112; lncRNA-N3
External IDsOMIM114204 MGI88295 HomoloGene579 ChEMBL: 1919 GeneCards: CACNA2D1 Gene
RNA expression pattern
File:PBB GE CACNA2D1 207050 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez78112293
EnsemblENSG00000153956ENSMUSG00000040118
UniProtP54289O08532
RefSeq (mRNA)NM_000722NM_001110843
RefSeq (protein)NP_000713NP_001104313
Location (UCSC)Chr 7:
81.95 – 82.44 Mb
Chr 5:
15.93 – 16.37 Mb
PubMed search[1][2]

Voltage-dependent calcium channel subunit alpha-2/delta-1 is a protein that in humans is encoded by the CACNA2D1 gene.[1][2]

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[2]

Gabapentinoids

alpha2/delta proteins are believed to be the molecular target of the gabapentinoids gabapentin and pregabalin, which are used to treat epilepsy and neuropathic pain.[3]

See also

References

  1. ^ Powers PA, Scherer SW, Tsui LC, Gregg RG, Hogan K (Jun 1994). "Localization of the gene encoding the alpha 2/delta subunit (CACNL2A) of the human skeletal muscle voltage-dependent Ca2+ channel to chromosome 7q21-q22 by somatic cell hybrid analysis". Genomics 19 (1): 192–3. PMID 8188232. doi:10.1006/geno.1994.1044. 
  2. ^ a b "Entrez Gene: CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1". 
  3. ^ Rogawski MA, Bazil CW (July 2008). "New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels". Curr Neurol Neurosci Rep 8 (4): 345–52. PMC 2587091. PMID 18590620. doi:10.1007/s11910-008-0053-7. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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