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CACNB1

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Identifiers
SymbolsCACNB1 ; CAB1; CACNLB1; CCHLB1
External IDsOMIM114207 MGI102522 HomoloGene20186 GeneCards: CACNB1 Gene
RNA expression pattern
File:PBB GE CACNB1 210185 at tn.png
File:PBB GE CACNB1 206996 x at tn.png
File:PBB GE CACNB1 210967 x at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez78212295
EnsemblENSG00000067191ENSMUSG00000020882
UniProtQ02641Q8R3Z5
RefSeq (mRNA)NM_000723NM_001159319
RefSeq (protein)NP_000714NP_001152791
Location (UCSC)Chr 17:
37.33 – 37.35 Mb
Chr 11:
98 – 98.02 Mb
PubMed search[1][2]

Voltage-dependent L-type calcium channel subunit beta-1 is a protein that in humans is encoded by the CACNB1 gene.[1][2][3]

The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[3]

See also

References

  1. Gregg RG, Powers PA, Hogan K (Mar 1993). "Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping". Genomics 15 (1): 185–7. PMID 8381767. doi:10.1006/geno.1993.1029. 
  2. Iles DE, Segers B, Sengers RC, Monsieurs K, Heytens L, Halsall PJ, Hopkins PM, Ellis FR, Hall-Curran JL, Stewart AD et al. (Oct 1993). "Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility". Hum Mol Genet 2 (7): 863–8. PMID 8395940. doi:10.1093/hmg/2.7.863. 
  3. 3.0 3.1 "Entrez Gene: CACNB1 calcium channel, voltage-dependent, beta 1 subunit". 

Further reading

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External links

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