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CAMK2G

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Identifiers
SymbolsCAMK2G ; CAMK; CAMK-II; CAMKG
External IDsOMIM602123 MGI88259 HomoloGene15596 IUPHAR: 1557 ChEMBL: 3829 GeneCards: CAMK2G Gene
EC number2.7.11.17
RNA expression pattern
File:PBB GE CAMK2G 212669 at tn.png
File:PBB GE CAMK2G 212757 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez81812325
EnsemblENSG00000148660ENSMUSG00000021820
UniProtQ13555Q923T9
RefSeq (mRNA)NM_001204492NM_001039138
RefSeq (protein)NP_001191421NP_001034227
Location (UCSC)Chr 10:
75.57 – 75.63 Mb
Chr 14:
20.73 – 20.79 Mb
PubMed search[1][2]

Calcium/calmodulin-dependent protein kinase type II gamma chain is an enzyme that in humans is encoded by the CAMK2G gene.[1]

Function

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined.[2]

See also

Ca2+/calmodulin-dependent protein kinase

Interactions

CAMK2G has been shown to interact with RRAD.[3]

References

  1. ^ Li X, Nghiem P, Schulman H, Francke U (Feb 1994). "Localization of the CAMKG gene encoding gamma isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14". Cytogenet Cell Genet 66 (2): 113–6. PMID 8287681. doi:10.1159/000133679. 
  2. ^ "Entrez Gene: CAMK2G calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma". 
  3. ^ Moyers JS, Bilan PJ, Zhu J, Kahn CR (May 1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): 11832–9. PMID 9115241. doi:10.1074/jbc.272.18.11832. 

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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