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Open Access Articles- Top Results for CD11a

CD11a

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Identifiers
SymbolsITGAL ; CD11A; LFA-1; LFA1A
External IDsOMIM153370 MGI96606 HomoloGene1666 IUPHAR: 2451 ChEMBL: 1803 GeneCards: ITGAL Gene
RNA expression pattern
File:PBB GE ITGAL 213475 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez368316408
EnsemblENSG00000005844ENSMUSG00000030830
UniProtP20701P24063
RefSeq (mRNA)NM_001114380NM_001253872
RefSeq (protein)NP_001107852NP_001240801
Location (UCSC)Chr 16:
30.48 – 30.53 Mb
Chr 7:
127.3 – 127.34 Mb
PubMed search[1][2]

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab.

Function

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling.[1]

CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.

Efalizumab acts as an immunosuppressant by binding to CD11a.

Interactions

CD11a has been shown to interact with ICAM-1.[2][3][4]

See also

References

  1. ^ "Entrez Gene: ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)". 
  2. ^ Lu C, Takagi J, Springer TA (May 2001). "Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state". J. Biol. Chem. 276 (18): 14642–8. PMID 11279101. doi:10.1074/jbc.M100600200. 
  3. ^ Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD et al. (Jan 2003). "Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation". Cell 112 (1): 99–111. PMID 12526797. doi:10.1016/S0092-8674(02)01257-6. 
  4. ^ Yusuf-Makagiansar H, Makagiansar IT, Hu Y, Siahaan TJ (Dec 2001). "Synergistic inhibitory activity of alpha- and beta-LFA-1 peptides on LFA-1/ICAM-1 interaction". Peptides 22 (12): 1955–62. PMID 11786177. doi:10.1016/S0196-9781(01)00546-0. 

Further reading

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External links

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