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CD11c

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Identifiers
SymbolsITGAX ; CD11C; SLEB6
External IDsOMIM151510 MGI96609 HomoloGene55493 IUPHAR: 2454 ChEMBL: 4733 GeneCards: ITGAX Gene
RNA expression pattern
File:PBB GE ITGAX 210184 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez368716411
EnsemblENSG00000140678ENSMUSG00000030789
UniProtP20702Q9QXH4
RefSeq (mRNA)NM_000887NM_021334
RefSeq (protein)NP_000878NP_067309
Location (UCSC)Chr 16:
31.37 – 31.39 Mb
Chr 7:
128.13 – 128.15 Mb
PubMed search[1][2]

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c .[1] [2]

CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.[1]

CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

See also

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Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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