Open Access Articles- Top Results for CD137


SymbolsTNFRSF9 ; 4-1BB; CD137; CDw137; ILA
External IDsOMIM602250 MGI1101059 HomoloGene1199 IUPHAR: 1878 GeneCards: TNFRSF9 Gene
RNA expression pattern
File:PBB GE TNFRSF9 207536 s at tn.png
File:PBB GE TNFRSF9 211786 at tn.png
More reference expression data
RefSeq (mRNA)NM_001561NM_001077508
RefSeq (protein)NP_001552NP_001070976
Location (UCSC)Chr 1:
7.98 – 8 Mb
Chr 4:
150.91 – 150.95 Mb
PubMed search[1][2]

CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA).


CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.

Specific effects on cells

The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.


CD137 has been shown to interact with TRAF2.[1][2]

See also


  1. ^ Jang IK, Lee ZH, Kim YJ, Kim SH, Kwon BS (Jan 1998). "Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B". Biochem. Biophys. Res. Commun. 242 (3): 613–20. PMID 9464265. doi:10.1006/bbrc.1997.8016. 
  2. ^ Arch RH, Thompson CB (Jan 1998). "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB". Mol. Cell. Biol. 18 (1): 558–65. PMC 121523. PMID 9418902. 

Further reading