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CD160

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Identifiers
SymbolsCD160 ; BY55; NK1; NK28
External IDsOMIM604463 MGI1860383 HomoloGene5122 GeneCards: CD160 Gene
RNA expression pattern
File:PBB GE CD160 207840 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1112654215
EnsemblENSG00000117281ENSMUSG00000038304
UniProtO95971O88875
RefSeq (mRNA)NM_007053NM_001163496
RefSeq (protein)NP_008984NP_001156968
Location (UCSC)Chr 1:
145.7 – 145.72 Mb
Chr 3:
96.8 – 96.83 Mb
PubMed search[1][2]

CD160 antigen is a protein that in humans is encoded by the CD160 gene.[1][2][3]

CD160 is a 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.[3]

Clinical significance

CD160 as a potential new target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs.


Related gene problems

See also

References

  1. ^ Anumanthan A, Bensussan A, Boumsell L, Christ AD, Blumberg RS, Voss SD, Patel AT, Robertson MJ, Nadler LM, Freeman GJ (Oct 1998). "Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes". J Immunol 161 (6): 2780–90. PMID 9743336. 
  2. ^ Agrawal S, Marquet J, Freeman GJ, Tawab A, Bouteiller PL, Roth P, Bolton W, Ogg G, Boumsell L, Bensussan A (Apr 1999). "Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells". J Immunol 162 (3): 1223–6. PMID 9973372. 
  3. ^ a b "Entrez Gene: CD160 CD160 molecule". 
  4. ^ Klopocki E, Schulze H, Strauss G et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". Am. J. Hum. Genet. 80 (2): 232–40. PMC 1785342. PMID 17236129. doi:10.1086/510919. 

Further reading

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External links

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Skin Research Center lab Hopital St Louis, Paris (France) Dir. Dr. A. Bensussan