Adverts

Open Access Articles- Top Results for CD1D

CD1D

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsCD1D ; CD1A; R3
External IDsOMIM188410 MGI107674 HomoloGene1337 ChEMBL: 1649053 GeneCards: CD1D Gene
RNA expression pattern
File:PBB GE CD1D 205789 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez91212479
EnsemblENSG00000158473ENSMUSG00000028076
UniProtP15813P11609
RefSeq (mRNA)NM_001766NM_007639
RefSeq (protein)NP_001757NP_031665
Location (UCSC)Chr 1:
158.15 – 158.15 Mb
Chr 3:
87 – 87 Mb
PubMed search[1][2]

CD1D is the human gene that encodes the protein CD1d,[1] a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are non-classical MHC proteins, related to the class I MHC proteins, and are involved in the presentation of lipid antigens to T cells. CD1d is the only member of the group 2 CD1 molecules.

Biological significance

CD1d-presented lipid antigens activate a special class of T cells, known as natural killer T (NKT) cells, through the interaction with the T-cell receptor present on NKT membranes.[1] When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and interleukin 4 production.

Nomenclature

CD1d is also known as R3G1

Ligands

Some of the known ligands for CD1d are:

CD1d tetramers

CD1d tetramers are protein constructs composed of four CD1d molecules joined together and usually fluorescently labelled, used to identify NKT cells or other CD1d-reactive cells. In particular, type I NKT cells and some type II NKT cells are stained by them. A differentiation of these two types can be obtained in human by using an antibody against the TCR Vα24 chain, which is specific of type I NKT cells.[6]

Although they are the most widely used of CD1d oligomers, sometimes CD1d dimers (two units) or pentamers (five units) are used instead.[6]

References

  1. ^ a b "P15813 (CD1D_HUMAN)". Uniprot. Retrieved 1 March 2013. 
  2. ^ Franck, Richard W. (1 January 2012). "C-Galactosylceramide: Synthesis and Immunology". C R Chim. 15 (1): 46–56. PMC 3293403. PMID 22408579. doi:10.1016/j.crci.2011.05.006. 
  3. ^ Bendelac, A; Savage PB; Teyton I (2007). "The Biology of NKT Cells". Annual Review of Immunology 25 (1): 297–336. PMID 17150027. doi:10.1146/annurev.immunol.25.022106.141711. 
  4. ^ Zhou, D (August 2006). "The immunological function of iGb3". Current Protein & Peptide Science 7 (4): 325–323. PMID 16918447. doi:10.2174/138920306778018007. Retrieved 4 March 2013. 
  5. ^ J. Kerzerho, E. Yu, C. M. Barra, E. Alari-Pahissa, E. Girardi, Y. Harrak, P. Lauzurica, A. Llebaria, D. Zajonc, O. Akbari, A. R. Castaño (2012). "Structural and functional characterization of a novel non-glycosidic iNKT agonist with immunomodulatory properties". Journal of Immunology 188: 2254–2265. PMID 22301545. doi:10.4049/jimmunol.1103049. 
  6. ^ a b Terabe, Masaki; Berzofsky, Jay A. (2008). "The Role of NKT Cells in Tumor Immunity". Adv Cancer Res 101: 277–348. PMC 2693255. PMID 19055947. doi:10.1016/S0065-230X(08)00408-9. Retrieved 8 March 2013. 

Further reading

</dl>

External links