T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene.
The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The gene is 87,896 bases in length. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons.
T-cell receptor zeta, together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
CD247 has been shown to interact with Janus kinase 3 and Protein unc-119 homolog.
- ^ Weissman AM, Hou D, Orloff DG, Modi WS, Seuanez H, O'Brien SJ et al. (December 1988). "Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9709–13. PMC 282845. PMID 2974162. doi:10.1073/pnas.85.24.9709.
- ^ "Entrez Gene: CD247 CD247 molecule".
- ^ Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H et al. (Jul 2001). "Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex". J. Biol. Chem. 276 (27): 25378–85. PMID 11349123. doi:10.1074/jbc.M011363200.
- ^ Gorska MM, Stafford SJ, Cen O, Sur S, Alam R (Feb 2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation". J. Exp. Med. 199 (3): 369–79. PMC 2211793. PMID 14757743. doi:10.1084/jem.20030589.
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