Open Access Articles- Top Results for CD247


SymbolsCD247 ; CD3-ZETA; CD3H; CD3Q; CD3Z; T3Z; TCRZ
External IDsOMIM186780 MGI88334 HomoloGene12818 GeneCards: CD247 Gene
RNA expression pattern
File:PBB GE CD247 210031 at tn.png
More reference expression data
RefSeq (mRNA)NM_000734NM_001113391
RefSeq (protein)NP_000725NP_001106862
Location (UCSC)Chr 1:
167.4 – 167.49 Mb
Chr 1:
165.79 – 165.88 Mb
PubMed search[1][2]

T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene.[1]


The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The gene is 87,896 bases in length. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons.


T-cell receptor zeta, together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]


CD247 has been shown to interact with Janus kinase 3[3] and Protein unc-119 homolog.[4]

See also


  1. ^ Weissman AM, Hou D, Orloff DG, Modi WS, Seuanez H, O'Brien SJ et al. (December 1988). "Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9709–13. PMC 282845. PMID 2974162. doi:10.1073/pnas.85.24.9709. 
  2. ^ "Entrez Gene: CD247 CD247 molecule". 
  3. ^ Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H et al. (Jul 2001). "Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex". J. Biol. Chem. 276 (27): 25378–85. PMID 11349123. doi:10.1074/jbc.M011363200. 
  4. ^ Gorska MM, Stafford SJ, Cen O, Sur S, Alam R (Feb 2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation". J. Exp. Med. 199 (3): 369–79. PMC 2211793. PMID 14757743. doi:10.1084/jem.20030589. 

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