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CD37

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsCD37 ; GP52-40; TSPAN26
External IDsOMIM151523 MGI88330 HomoloGene20422 GeneCards: CD37 Gene
RNA expression pattern
File:PBB GE CD37 204192 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez95112493
EnsemblENSG00000104894ENSMUSG00000030798
UniProtP11049Q61470
RefSeq (mRNA)NM_001040031NM_001290802
RefSeq (protein)NP_001035120NP_001277731
Location (UCSC)Chr 19:
49.84 – 49.85 Mb
Chr 7:
45.23 – 45.24 Mb
PubMed search[1][2]

Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.[1][2]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.[2]

See also

References

  1. ^ Virtaneva KI, Angelisova P, Baumruker T, Horejsi V, Nevanlinna H, Schroder J (Mar 1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics 37 (6): 461–465. PMID 8436422. doi:10.1007/BF00222471. 
  2. ^ a b "Entrez Gene: CD37 CD37 molecule". 

Further reading

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External links

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