Open Access Articles- Top Results for CD43


SymbolsSPN ; CD43; GALGP; GPL115; LSN
External IDsOMIM182160 MGI98384 HomoloGene36108 GeneCards: SPN Gene
RefSeq (mRNA)NM_001030288NM_001037810
RefSeq (protein)NP_001025459NP_001032899
Location (UCSC)Chr 16:
29.67 – 29.68 Mb
Chr 7:
127.13 – 127.14 Mb
PubMed search[1][2]

Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene.[1][2][3]


Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.[1]

Clinical significance

Defects in the CD43 molecule are associated with the development of Wiskott-Aldrich syndrome.[4] It also appears in about 25% of intestinal MALTomas.[citation needed] Using immunohistochemistry, CD43 can be demonstrated in the paracortical T-cells of healthy lymph nodes and tonsils; it is also positive in a range of lymphoid and myeloid tumours. Although it is present in over 90% of T-cell lymphomas, it is generally less effective at demonstrating this condition than is CD3 antigen. However, it may be useful as part of a panel to demonstrate B-cell lymphoblastic lymphoma, since the malignant cells in this condition are often CD43 positive, and may be difficult to stain with other antibodies. Because it stains granulocytes and their precursors, it is also an effective marker for myeloid tumours.[5]


CD43 has been shown to interact with EZR[6] and Moesin.[6][7]


  1. ^ a b "Entrez Gene: SPN sialophorin (leukosialin, CD43)". 
  2. ^ Pallant A, Eskenazi A, Mattei MG, Fournier RE, Carlsson SR, Fukuda M, Frelinger JG (February 1989). "Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16". Proc. Natl. Acad. Sci. U.S.A. 86 (4): 1328–32. Bibcode:1989PNAS...86.1328P. PMC 286683. PMID 2521952. doi:10.1073/pnas.86.4.1328. 
  3. ^ Shelley CS, Remold-O'Donnell E, Davis AE, Bruns GA, Rosen FS, Carroll MC, Whitehead AS (April 1989). "Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome". Proc. Natl. Acad. Sci. U.S.A. 86 (8): 2819–23. Bibcode:1989PNAS...86.2819S. PMC 287010. PMID 2784859. doi:10.1073/pnas.86.8.2819. 
  4. ^ Remold-O'Donnell E, Rosen FS (1990). "Sialophorin (CD43) and the Wiskott-Aldrich syndrome". Immunodefic Rev 2 (2): 151–74. PMID 2223062. 
  5. ^ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. p. 113. ISBN 1-84110-100-1. 
  6. ^ a b Serrador JM, Nieto M, Alonso-Lebrero JL, del Pozo MA, Calvo J, Furthmayr H, Schwartz-Albiez R, Lozano F, González-Amaro R, Sánchez-Mateos P, Sánchez-Madrid F (June 1998). "CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts". Blood 91 (12): 4632–44. PMID 9616160. 
  7. ^ Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S (February 1998). "Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2". J. Cell Biol. 140 (4): 885–95. PMC 2141743. PMID 9472040. doi:10.1083/jcb.140.4.885. 

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