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Open Access Articles- Top Results for CD49a

CD49a

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Identifiers
SymbolsITGA1 ; CD49a; VLA1
External IDsOMIM192968 MGI96599 HomoloGene57137 IUPHAR: 2437 ChEMBL: 3682 GeneCards: ITGA1 Gene
Orthologs
SpeciesHumanMouse
Entrez3672109700
EnsemblENSG00000213949ENSMUSG00000042284
UniProtP56199Q3V3R4
RefSeq (mRNA)NM_181501NM_001033228
RefSeq (protein)NP_852478NP_001028400
Location (UCSC)Chr 5:
52.08 – 52.26 Mb
Chr 13:
114.96 – 115.1 Mb
PubMed search[1][2]

CD49a is an integrin alpha subunit. It makes up half of the α1β1 integrin duplex.

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.[1]

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