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Open Access Articles- Top Results for CD49d

CD49d

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Identifiers
SymbolsITGA4 ; CD49D; IA4
External IDsOMIM192975 MGI96603 HomoloGene37364 IUPHAR: 2443 ChEMBL: 278 GeneCards: ITGA4 Gene
RNA expression pattern
File:PBB GE ITGA4 213416 at tn.png
File:PBB GE ITGA4 205884 at tn.png
File:PBB GE ITGA4 205885 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez367616401
EnsemblENSG00000115232ENSMUSG00000027009
UniProtP13612Q00651
RefSeq (mRNA)NM_000885NM_010576
RefSeq (protein)NP_000876NP_034706
Location (UCSC)Chr 2:
182.32 – 182.4 Mb
Chr 2:
79.26 – 79.33 Mb
PubMed search[1][2]

CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor.

Function

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.[1]

Interactions

CD49d has been shown to interact with LGALS8[2] and Paxillin.[3][4]

References

  1. ^ "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)". 
  2. ^ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R et al. (2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell. Sci. 113 (Pt 13): 2385–97. PMID 10852818. 
  3. ^ Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH (November 2001). "Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding". J. Biol. Chem. 276 (44): 40903–9. PMID 11533025. doi:10.1074/jbc.M102665200. 
  4. ^ Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD et al. (June 2002). "A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration". J. Biol. Chem. 277 (23): 20887–94. PMID 11919182. doi:10.1074/jbc.M110928200. 

Further reading

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External links

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