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Open Access Articles- Top Results for CD86

CD86

This article is about the molecule. For the compilation album, see CD86 (album).
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Identifiers
SymbolsCD86 ; B7-2; B7.2; B70; CD28LG2; LAB72
External IDsOMIM601020 MGI101773 HomoloGene10443 IUPHAR: 2745 GeneCards: CD86 Gene
RNA expression pattern
File:PBB GE CD86 205686 s at tn.png
File:PBB GE CD86 205685 at tn.png
File:PBB GE CD86 210895 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez94212524
EnsemblENSG00000114013ENSMUSG00000022901
UniProtP42081P42082
RefSeq (mRNA)NM_001206924NM_019388
RefSeq (protein)NP_001193853NP_062261
Location (UCSC)Chr 3:
121.77 – 121.84 Mb
Chr 16:
36.6 – 36.67 Mb
PubMed search[1][2]

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.

The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily.[1] Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.[2]

Clinical significance

See also

References

  1. ^ Chen C, Gault A, Shen L, Nabavi N (May 1994). "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". J. Immunol. 152 (10): 4929–36. PMID 7513726. 
  2. ^ "Entrez Gene: CD86 CD86 molecule". 

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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