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Open Access Articles- Top Results for CD8A

CD8A

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Identifiers
SymbolsCD8A ; CD8; Leu2; MAL; p32
External IDsOMIM186910 MGI88346 HomoloGene133777 GeneCards: CD8A Gene
RNA expression pattern
File:PBB GE CD8A 205758 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez92512525
EnsemblENSG00000153563ENSMUSG00000053977
UniProtP01732P01731
RefSeq (mRNA)NM_001145873NM_001081110
RefSeq (protein)NP_001139345NP_001074579
Location (UCSC)Chr 2:
87.01 – 87.04 Mb
Chr 6:
71.37 – 71.38 Mb
PubMed search[1][2]

CD8a (Cluster of Differentiation 8a), is a human gene.[1]

Function

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.[1]

Interactions

CD8A has been shown to interact with:

See also

References

  1. ^ a b "Entrez Gene: CD8A CD8a molecule". 
  2. ^ Doucey MA, Goffin L, Naeher D, Michielin O, Baumgärtner P, Guillaume P et al. (January 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. 278 (5): 3257–64. PMID 12215456. doi:10.1074/jbc.M208119200. 
  3. ^ a b Gao GF, Willcox BE, Wyer JR, Boulter JM, O'Callaghan CA, Maenaka K et al. (May 2000). "Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha". J. Biol. Chem. 275 (20): 15232–8. PMID 10809759. doi:10.1074/jbc.275.20.15232. 
  4. ^ Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI et al. (June 1997). "Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2". Nature 387 (6633): 630–4. PMID 9177355. doi:10.1038/42523. 
  5. ^ Sanders SK, Giblin PA, Kavathas P (September 1991). "Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts". J. Exp. Med. 174 (3): 737–40. PMC 2118947. PMID 1908512. doi:10.1084/jem.174.3.737. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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