Open Access Articles- Top Results for CDC42


SymbolsCDC42 ; CDC42Hs; G25K
External IDsOMIM116952 MGI106211 HomoloGene123986 ChEMBL: 6088 GeneCards: CDC42 Gene
RNA expression pattern
File:PBB GE CDC42 208728 s at tn.png
File:PBB GE CDC42 208727 s at tn.png
File:PBB GE CDC42 210232 at tn.png
More reference expression data
RefSeq (mRNA)NM_001039802NM_001243769
RefSeq (protein)NP_001034891NP_001230698
Location (UCSC)Chr 1:
22.38 – 22.42 Mb
Chr 4:
137.32 – 137.36 Mb
PubMed search[1][2]

Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene.[1][2]


Human CDC42 is a small GTPase of the Rho family, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.[3]


CDC42 has been shown to interact with:


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  3. ^ "Entrez Gene: CDC42 cell division cycle 42 (GTP binding protein, 25kDa)". 
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  25. ^ Gibson, R M; Wilson-Delfosse A L (October 2001). "RhoGDI-binding-defective mutant of Cdc42Hs targets to membranes and activates filopodia formation but does not cycle with the cytosol of mammalian cells". Biochem. J. (England) 359 (Pt 2): 285–94. ISSN 0264-6021. PMC 1222146. PMID 11583574. doi:10.1042/0264-6021:3590285. 
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