Adverts

Open Access Articles- Top Results for CDH11

CDH11

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsCDH11 ; CAD11; CDHOB; OB; OSF-4
External IDsOMIM600023 MGI99217 HomoloGene1361 GeneCards: CDH11 Gene
RNA expression pattern
File:PBB GE CDH11 207172 s at tn.png
File:PBB GE CDH11 207173 x at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez100912552
EnsemblENSG00000140937ENSMUSG00000031673
UniProtP55287P55288
RefSeq (mRNA)NM_001797NM_009866
RefSeq (protein)NP_001788NP_033996
Location (UCSC)Chr 16:
64.98 – 65.16 Mb
Chr 8:
102.63 – 102.79 Mb
PubMed search[1][2]

Cadherin-11 is a protein that in humans is encoded by the CDH11 gene.[1][2]

Function

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.[2] The mammalian CDH-11 homologues are termed calsyntenin.[3]

Relevance to cancer

CDH11 is overexpressed in 15% of breast cancers and seems essential to tumour progression in some other cancer types.[4][5]

Drug interactions

Arthritis drug celecoxib binds to CDH11.[4][5]

Interactions

CDH11 has been shown to interact with CDH2.[6]

References

  1. ^ Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics 49 (3): 467–71. PMID 9615235. doi:10.1006/geno.1998.5281. 
  2. ^ a b "Entrez Gene: CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)". 
  3. ^ Vogt L, Schrimpf SP, Meskenaite V, Frischknecht R, Kinter J, Leone DP et al. (2001). "Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain". Mol. Cell. Neurosci. 17 (1): 151–66. PMID 11161476. doi:10.1006/mcne.2000.0937. 
  4. ^ a b "New Therapeutic Approach Could Target Both Cancer and Arthritis". 15 Nov 2013. 
  5. ^ a b Assefnia S, Dakshanamurthy S, Guidry Auvil JM, Hampel C, Anastasiadis PZ, Kallakury B et al. (Mar 2014). "Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies.". Oncotarget 5 (6): 1458–74. PMID 24681547. 
  6. ^ Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T et al. (Dec 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell. Sci. 116 (Pt 24): 4985–95. PMID 14625392. doi:10.1242/jcs.00815. 


Further reading

</dl>

External links

Template:Gene-16-stub