Open Access Articles- Top Results for CDH6


SymbolsCDH6 ; CAD6; KCAD
External IDsOMIM603007 MGI107435 HomoloGene21027 GeneCards: CDH6 Gene
RNA expression pattern
File:PBB GE CDH6 205532 s at tn.png
File:PBB GE CDH6 205533 s at tn.png
File:PBB GE CDH6 210602 s at tn.png
More reference expression data
RefSeq (mRNA)NM_004932NM_007666
RefSeq (protein)NP_004923NP_031692
Location (UCSC)Chr 5:
31.19 – 31.33 Mb
Chr 15:
13.03 – 13.17 Mb
PubMed search[1][2]

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.[1][2][3]

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.[3]


  1. ^ Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S (Jun 1995). "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells". Cancer Res 55 (10): 2206–11. PMID 7743525. 
  2. ^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics 57 (1): 160–3. PMID 10191097. doi:10.1006/geno.1998.5717. 
  3. ^ a b "Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)". 

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